論文一覧

2022年

  1. Akiyama T, Kuki I, Kim K, Yamamoto N, Yamada Y, Igarashi K, Ishihara T, Hatano Y, Kobayashi K.
    Folic acid inhibits 5-methyltetrahydrofolate transport across the blood–cerebrospinal fluid barrier: clinical biochemical data from two cases.
    JIMD Rep, in press.
  2. Hyodo Y, Akiyama T, Fukuyama T, Mimaki M, Watanabe K, Kumagai T, Kobayashi K.
    Simultaneous assay of urine sepiapterin and creatinine in patients with sepiapterin reductase deficiency.
    Clin Chim Acta, in press.
  3. Kobayashi K, Shibata T, Tsuchiya H, Akiyama T.
    Artificial intelligence-based detection of epileptic discharges from pediatric scalp electroencephalograms: A pilot study.
    Acta Med Okayama, in press.
  4. Sugiyama Y, Watanabe T, Tajika M, Matsuhashi T, Shimura M, Fushimi T, Ichimoto K, Matsunaga A, Ebihara T, Tsuruoka T, Akiyama T, Murayama K.
    A Japanese single-center experience of the efficacy and safety of asfotase alfa in pediatric-onset hypophosphatasia.
    Orphanet J Rare Dis 2022;17:78. PMID: 35197081
  5. Kato M, Kada A, Shiraishi H, Tohyama J, Nakagawa E, Takahashi Y, Akiyama T, Kakita A, Miyake N, Fujita A, Saito MA, Inoue Y.
    Sirolimus for epileptic seizures associated with focal cortical dysplasia type II.
    Ann Clin Transl Neurol 2022;9:181-192. PMID: 35040598

2021年

  1. Takeuchi A, Inoue T, Nakamura M, Kageyama M, Akiyama T, Kobayashi K.
    Case Report: High-gamma oscillations on an ictal electroencephalogram in a newborn patient with hypoxic-ischemic encephalopathy.
    Front Pediatr 2021;9:679771. PMID: 34660474
  2. Kada A, Tohyama J, Shiraishi H, Takahashi Y, Nakagawa E, Akiyama T, Saito MA, Inoue Y, Kato M.
    A single-arm open-label clinical trial on the efficacy and safety of sirolimus for epileptic seizures associated with focal cortical dysplasia type II: a study protocol.
    Kurume Med J 2021;66:115-120. PMID: 34135202
  3. Kobayashi K, Shibata T, Tsuchiya H, Akiyama T.
    Exclusion of the possibility of “false ripples” from ripple band high-frequency oscillations recorded from scalp electroencephalogram in children with epilepsy.
    Front Hum Neurosci 2021; 15: 696882. PMID: 34211382
  4. Oka M, Kobayashi K, Shibata T, Tsuchiya H, Hanaoka Y, Akiyama M, Morooka T, Akiyama T.
    A study on the relationship between non-epileptic fast (40-200Hz) oscillations in scalp EEG and development in children.
    Brain Dev 2021;43:904-911. PMID: 34052035
  5. Hanaoka Y, Akiyama T, Yoshinaga H, Miyamoto R, Kawarai T, Kaji R, Kobayashi K.
    Monozygotic twins with DYT-TOR1A showing jerking movements and levodopa responsiveness.
    Brain Dev 2021; 43: 783-788. PMID: 33832800
  6. Shibata T, Kawai H, Sakamoto S, Tsutsui K, Kanbayashi T, Tanaka K, Takaki M.
    Rituximab was effective for treatment of anti-N-methyl-d-aspartate receptor encephalitis in early adolescence in initially suspected dissociative disorder.
    Clin Neuropharmacol 2021; 44: 99-100. PMID: 33587488
  7. Miyata H, Fushimi S, Ota Y, Vinters HV, Adachi K, Nanba E, Akiyama T.
    Isolated cortical tuber in an infant with genetically confirmed tuberous sclerosis complex 1 presenting with symptomatic West syndrome.
    Neuropathology 2021; 41: 58-64. PMID: 33181865
  8. Furui A, Onishi R, Takeuchi A, Akiyama T, Tsuji T.
    Non-Gaussianity detection of EEG signals based on a multivariate scale mixture model for diagnosis of epileptic seizures.
    IEEE Biomed Trans Eng 2021; 68: 515-525. PMID: 32746048

2020年

  1. Takagi M, Kato S, Muto T, Sano Y, Akiyama T, Takagi J, Okumura A, Iwayama H.
    Odontohypophosphatasia treated with asfotase alfa enzyme replacement therapy in a toddler: a case report.
    Clin Pediatr Endocrinol 2020; 29: 115-118. PMID: 32694888
  2. Akiyama T, Hyodo Y, Hasegawa K, Oboshi T, Imai K, Ishihara N, Dowa Y, Koike T, Yamamoto T, Shibasaki J, Shimbo H, Fukuyama T, Takano K, Shiraku H, Takeshita S, Okanishi T, Baba S, Kubota M, Hamano S, Kobayashi K.
    Pyridoxal in the cerebrospinal fluid may be a better indicator of vitamin B6-dependent epilepsy than pyridoxal 5′-phosphate.
    Pediatr Neurol 2020; 113: 33-41. PMID: 32980745
  3. Nishizawa H, Sato Y, Ishikawa M, Arakawa Y, Iijima M, Akiyama T, Takano K, Watanabe A, Kosho T.
    Marked improvement in motor function in a 32 year-old woman with childhood hypophosphatasia through asfotase alfa therapy: evaluation based on standardized batteries used in Duchenne muscular dystrophy clinical trials.
    Mol Genet Metab Rep 2020; 25: 100643. PMID: 32983894
  4. Tsuchiya H, Endoh F, Akiyama T, Matsuhashi M, Kobayashi K.
    Longitudinal correspondence of epilepsy and scalp EEG fast (40-200 Hz) oscillations in pediatric patients with tuberous sclerosis complex.
    Brain Dev 2020; 42: 663-674. PMID: 32631641
  5. Shibata T, Otsubo H.
    Phase-amplitude coupling of delta brush unveiling neuronal modulation development in the neonatal brain.
    Neurosci Lett 2020; 735: 135211. PMID: 32593774
  6. Kuhara T, Akiyama T, Ohse M, Koike T, Shibasaki J, Imai K, Cooper AJL.
    Identification of new biomarkers of pyridoxine-dependent epilepsy by GC/MS-based urine metabolomics.
    Anal Biochem, 2020; 604: 113739. PMID: 32339489
  7. Akiyama T, Toda S, Kimura N, Mogami Y, Hanaoka Y, Tokorodani C, Ito T, Miyahara H, Hyodo Y, Kobayashi K.
    Vitamin B6 in acute encephalopathy with biphasic seizures and late reduced diffusion.
    Brain Dev 2020; 42: 402-407. PMID: 32107100
  8. Miyahara H, Akiyama T, Hasegawa K, Akiyama M, Oka M, Kobayashi K, Tsukahara H.
    Laboratory changes during ACTH therapy associated with renal calcified lesions.
    Pediatr Int 2020; 62: 587-592. PMID: 31957090
  9. Din F, Lalgudi Ganesan S, Akiyama T, Stewart CP, Ochi A, Otsubo H, Go C, Hahn CD.
    Seizure detection algorithms in critically ill children: A comparative evaluation.
    Crit Care Med 2020; 48: 545-552. PMID: 32205601
  10. Koyama H, Yasuda S, Kakoi S, Ohata Y, Shimizu Y, Hasegawa C, Hayakawa A, Akiyama T, Yagi T, Aotani D, Imaeda K, Ozono K, Kataoka H, Tanaka T.
    Effect of Asfotase Alfa on muscle weakness in a Japanese adult patient of hypophosphatasia with Low ALP levels.
    Internal Med 2020; 59: 811-815. PMID: 31787692
  11. Akiyama T, Saigusa D, Hyodo Y, Umeda K, Saijo R, Koshiba S, Kobayashi K.
    Metabolic profiling of the cerebrospinal fluid in pediatric epilepsy.
    Acta Med Okayama 2020; 74: 65-71. PMID: 32099251
  12. Okanari K, Maruyama S, Suzuki H, Shibata T, Pulcine E, Donner EJ, Otsubo H.
    Autonomic dysregulation in children with epilepsy with postictal generalized EEG suppression following generalized convulsive seizures.
    Epilepsy Behav 2020; 102: 106688. PMID: 31805503
  13. Kobayashi K, Endoh F, Ohmori I, Akiyama T.
    Action of antiepileptic drugs on neurons.
    Brain Dev 2020; 42: 2-5. PMID: 31351738

2019年

  1. Yanagishita T, Yamamoto-Shimojima K, Koike T, Nasu H, Takahashi Y, Akiyama T, Nagata S, Yamamoto T.
    Compound heterozygous ALDH7A1 mutation causes the hemi-allelic expression in a patient with pyridoxine-dependent epilepsy.
    Tokyo Women’s Med Univ J 2019; 3: 73-77. Journal website
  2. Yokoi K, Nakajima Y, Shinkai Y, Sano Y, Imamura M, Akiyama T, Yoshikawa T, Ito T, Kurahashi H.
    Clinical and genetic aspects of mild hypophosphatasia in Japanese patients.
    Mol Genet Metab Rep 2019; 21: 100515. PMID: 31641588
  3. Ohuchi Y, Akiyama T, Matsuhashi M, Kobayashi K.
    High-frequency oscillations in a spectrum of pediatric epilepsies characterized by sleep-activated spikes in scalp EEG.
    Clin Neurophysiol 2019; 130: 1971-1980. PMID: 31476703
  4. Momosaki K, Kido J, Matsumoto S, Taniguchi A, Akiyama T, Sawada T, Ozasa S, Nakamura K.
    The effect of S-adenosylmethionine treatment on neurobehavioral phenotypes in Lesch-Nyhan disease: a case report.
    Case Rep Neurol 2019; 11: 256-264. PMID: 31607891
  5. Yamamoto T, Imaizumi T, Yamamoto-Shimojima K, Lu Y, Yanagishita T, Shimada S, Chong PF, Kira R, Ueda R, Ishiyama A, Takeshita E, Momosaki K, Ozasa S, Akiyama T, Kobayashi K, Oomatsu H, Kitahara H, Yamaguchi T, Imai K, Kurahashi H, Okumura A, Oguni H, Seto T, Okamoto N.
    Genomic backgrounds of Japanese patients with undiagnosed neurodevelopmental disorders.
    Brain Dev 2019; 41: 776-782. PMID: 31171384
  6. Ishiguro T, Sugiyama Y, Ueda K, Muramatsu Y, Tsuda H, Kotani T, Michigami T, Tachikawa K, Akiyama T, Hayakawa M.
    Findings of amplitude-integrated electroencephalogram recordings and serum vitamin B6 metabolites in perinatal lethal hypophosphatasia during enzyme replacement therapy.
    Brain Dev 2019; 41: 721-725. PMID: 31000369
  7. Takeuchi A, Yorifuji T, Hattori M, Tamai K, Nakamura K, Nakamura M, Kageyama M, Kubo T, Ogino T, Kobayashi K, Doi H.
    Catch-up growth and behavioral development among preterm, small-for-gestational-age children: a nationwide Japanese population-based study.
    Brain Dev 2019; 41: 397-405. PMID: 30611596
  8. Tsuchiya H, Akiyama T, Kuhara T, Nakajima Y, Ohse M, Kurahashi H, Kato T, Maeda Y, Yoshinaga H, Kobayashi K.
    A case of dihydropyrimidinase deficiency incidentally detected by urine metabolome analysis.
    Brain Dev 2019; 41: 280-284. PMID: 30384990

2018年

  1. Shibata K, Kobayashi K.
    Epileptic high-frequency oscillations in scalp electroehcephalography.
    Acta Med Okayama 2018; 72: 325-329. PMID: 30140078
  2. Akiyama T, Kubota T, Ozono K, Michigami T, Kobayashi D, Takeyari S, Sugihara Y, Noda M, Harada D, Namba N, Suzuki A, Utoyama M, Kitanaka S, Uematsu M, Mitani Y, Matsunami K, Takishima S, Ogawa E, Kobayashi K.
    Pyridoxal 5′-phosphate and related metabolites in hypophosphatasia: effects of enzyme replacement therapy.
    Mol Genet Metab 2018; 125: 174-180. PMID: 30049651
  3. Miyahara H, Akiyama T, Waki K, Arakaki Y.
    Differential diagnosis of nonepileptic twilight state with convulsive manifestations after febrile seizures.
    Brain Dev 2018; 40: 781-785. PMID: 29866486
  4. Oyachi M, Harada D, Sakamoto N, Ueyama K, Kondo K, Kishimoto K, Izui M, Nagamatsu Y, Kashiwagi H, Yamamuro M, Tamura M, Kikuchi S, Akiyama T, Michigami T, Seino Y, Namba N.
    A case of perinatal hypophosphatasia with a novel mutation in the ALPL gene: clinical course and review of the literature.
    Clin Pediatr Endocrinol 2018; 27: 179-186. PMID: 30083035
  5. Takeuchi A, Koeda T, Ogino T, Oka M, Yorifuji T, Takayanagi T, Sato K, Sugino N, Bonno M, Nakamura M, Kageyama M.
    Intelligence test at preschool-age predicts reading difficulty among school-aged very low birth weight infants in Japan.
    Brain Dev 2018; 40: 735-742. PMID: 29793755
  6. Kobayashi K, Ohuchi Y, Shibata T, Hanaoka Y, Akiyama M, Oka M, Endoh F, Akiyama T.
    Detection of fast (40-150 Hz) oscillations from the ictal scalp EEG data of myoclonic seizures in pediatric patients.
    Brain Dev 2018; 40: 397-405. PMID: 29395662
  7. Iimura Y, Jones K, Takada L, Shimizu I, Koyama M, Hattori K, Okazawa Y, Nonoda Y, Asano E, Akiyama T, Go C, Ochi A, Snead OC 3rd, Donner EJ, Rutka JT, Drake JM, Otsubo H.
    Strong coupling between slow oscillations and wide fast ripples in children with epileptic spasms: Investigation of modulation index and occurrence rate.
    Epilepsia 2018; 50: 544-554. PMID: 29315516
  8. Takeuchi A, Yorifuji T, Nakamura K, Tamai K, Mori S, Nakamura M, Kageyama M, Kubo T, Ogino T, Kobayashi K, Doi H.
    Catch-up growth and neurobehavioral development among full term, small-for-gestational-age children: a nationwide Japanese population-based study.
    J Pediatr 2018; 192: 41-46. PMID: 29092752

2017年

  1. Frauscher B, Bartolomei F, Kobayashi K, Cimbalnik J, van’t Klooster MA, Rampp S, Otsubo H, Holler Y, Wu JY, Asano E, Engel J Jr, Kahane P, Jacobs J, Gotman J.
    High-frequency oscillations: The state of clinical research.
    Epilepsia 2017; 58: 1316-1329. PMID: 28666056
  2. Akiyama T, Hayashi Y, Hanaoka Y, Shibata T, Akiyama M, Tsuchiya H, Yamaguchi T, Kobayashi K.
    Pyridoxal 5′-phosphate, pyridoxal, and 4-pyridoxic acid in the paired serum and cerebrospinal fluid of children.
    Clin Chim Acta 2017; 472: 118-122. PMID: 28778380
  3. Shibata T, Kobayashi K, Yoshinaga H, Ono H, Shinpo M, Kagitani-Shimono K.
    Another case of glucose transporter 1 deficiency syndrome with periventricular calcification, cataracts, hemolysis, and pseudohyperkalemia.
    Neuropediatrics 2017; 48: 390-393. PMID: 28582795
  4. Kobayashi K, Akiyama T, Agari T, Sasaki T, Shibata T, Hanaoka Y, Akiyama M, Endoh F, Oka M, Date I.
    Significance of high-frequency electrical brain activity.
    Acta Med Okayama 2017; 71: 191-200. PMID: 28655938
  5. Iimura Y, Jones K, Hattori K, Okazawa Y, Noda A, Hoashi K, Nonoda Y, Asano E, Akiyama T, Go C, Ochi A, Snead OC III, Donner EJ, Rutka JT, Drake JM, Otsubo H.
    The epileptogenic high frequency oscillations skipping the motor area in children with multilobar drug-resistant epilepsy.
    Clin Neurophysiol 2017; 128: 1197-1205. PMID: 28521267
  6. Kobayashi K, Endoh F, Agari T, Akiyama T, Akiyama M, Hayashi Y, Shibata T, Hanaoka Y, Oka M, Yoshinaga H, Date I.
    Complex observation of scalp fast (40-150 Hz) oscillations in West syndrome and related disorders with structural brain pathology.
    Epilepsia Open 2017; 2: 260-266. PMID: 29588955
  7. Hanaoka Y, Yoshinaga H, Kobayashi K.
    A ten-year follow-up cohort study of childhood epilepsy: changes in epilepsy diagnosis with age.
    Brain Dev 2017; 39: 312-320. PMID: 27847129
  8. Akiyama T, Akiyama M, Hayashi Y, Shibata T, Hanaoka Y, Toda S, Imai K, Hamano S, Okanishi T, Yoshinaga H, Kobayashi K.
    Measurement of pyridoxal 5′-phosphate, pyridoxal, and 4-pyridoxic acid in the cerebrospinal fluid of children.
    Clin Chim Acta 2017; 466: 1-5. PMID: 28040557
  9. Kobayashi Y, Tohyama J, Akiyama T, Magara S, Kawashima H, Akasaka N, Nakashima M, Saitsu H, Matsumoto N.
    Severe leukoencephalopathy with cortical involvement and peripheral neuropathy due to FOLR1 deficiency.
    Brain Dev 2017; 39: 266-270. PMID: 27743887
  10. Ogino T, Hanafusa K, Morooka T, Takeuchi A, Oka M, Ohtsuka Y.
    Predicting the reading skill of Japanese children.
    Brain Dev 2017; 39: 112-121. PMID: 27637722
  11. Takeuchi A, Yorifuji T, Takahashi K, Nakamura M, Kageyama M, Kubo T, Ogino T, Kobayashi K, Doi H.
    Behavioral outcomes of school-aged full-term small-for-gestational-age infants: a nationwide Japanese population-based study.
    Brain Dev 2017; 39: 101-106. PMID: 27622852
  12. Akiyama T, Hayashi Y, Hanaoka Y, Shibata T, Akiyama M, Nakamura K, Tsuyusaki Y, Kubota M, Yoshinaga H, Kobayashi K.
    Simultaneous measurement of monoamine metabolites and 5-methyltetrahydrofolate in the cerebrospinal fluid of children.
    Clin Chim Acta 2017; 465: 5-10. PMID: 27940130
  13. Kobayashi Y, Hanaoka Y, Akiyama T, Ohmori I, Ouchida M, Yamamoto T, Oka M, Yoshinaga H, Kobayashi K.
    A case of Dravet syndrome with cortical myoclonus indicated by jerk-locked back-averaging of electroencephalogram data.
    Brain Dev 2017; 39:75-79. PMID: 27523882
  14. Akiyama T, Shibata T, Yoshinaga H, Kuhara T, Nakajima Y, Kato T, Maeda Y, Ohse M, Oka M, Kageyama M, Kobayashi K.
    A Japanese case of β-ureidopropionase deficiency with dysmorphic features.
    Brain Dev 2017; 39: 58-61. PMID: 27553092
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