Furui A, Onishi R, Akiyama T, Tsuji T. Epileptic seizure detection using a recurrent neural network with temporal features derived from a scale mixture EEG model. IEEE Access 2024; 12: 162814-162814. Journal website
Akiyama T, Saito S. Editorial comments on “Two cases of cerebrospinal fluid hypovolemia that had been interpreted as orthostatic dysregulation”. Brain Dev Case Rep 2024; 2: 100033. Journal website
Tsuchiya H, Shibata T, Sasaki T, Akiyama M, Akiyama T, Kobayashi K. A retrospective study on post-operative recovery of daily living activity after total corpus callosotomy. Brain Dev 2024; 10: 339-343. PMID: 39304424
Shibata T, Tsuchiya H, Akiyama M, Akiyama T, Kobayashi K. Modulation index predicts the effect of ethosuximide on developmental and epileptic encephalopathy with spike-and-wave activation in sleep. Epilepsy Res 2024; 202: 107359. PMID: 38582072
Oto Y, Suzuki D, Morita T, Inoue T, Nitta A, Murakami N, Abe Y, Hamada Y, Akiyama T, Matsubara T. A case report of odonto-hypophosphatasia with a novel variant in the ALPL gene. J Pediatr Endocrinol Metab. 2024; 37: 276-279. PMID: 38310522
Akiyama T, Saigusa D, Inoue T, Tokorodani C, Akiyama M, Michiue R, Mori A, Hishinuma E, Matsukawa N, Shibata T, Tsuchiya H, Kobayashi K. Exploration of urine metabolic biomarkers for new-onset, untreated pediatric epilepsy: A gas and liquid chromatography mass spectrometry-based metabolomics study. Brain Dev 2024; 46: 180-186. PMID: 38171994
2023年
Akiyama M, Akiyama T, Saitsu H, Tokioka Y, Tsukahara R, Tsuchiya H, Shibata T, Kobayashi K. A female patient with adolescent-onset progressive myoclonus epilepsy carrying a truncating MECP2 mutation. Brain Dev 2023; 45: 597-602. PMID: 37550174
Shibata T, Kondo M, Fukushima Y, Akiyama M, Akiyama T, Morooka T, Baba K, Ohtsuki S, Tsukahara H, Kasahara S, Kobayashi K. Epilepsy in children with congenital heart disease: risk factors and characteristic presentations. Pediatr Neurol 2023; 147: 28-35. PMID: 37542972
Tsuchiya H, Shibata T, Sasaki T, Inoue T, Date I, Akiyama T, Kobayashi K. Effective epilepsy surgery for post-traumatic West syndrome following abusive head trauma. Acta Med Okayama 2023; 77: 561-566. PMID: 37899268
Akiyama M, Akiyama T, Saigusa D, Hishinuma E, Matsukawa N, Shibata T, Tsuchiya H, Mori A, Fujii Y, Mogami Y, Tokorodani C, Kuwahara K, Numata-Uematsu Y, Inoue K, Kobayashi K. Comprehensive study of metabolic changes induced by a ketogenic diet therapy using GC/MS- and LC/MS-based metabolomics. Seizure 2023; 107: 52-59. PMID: 36958064
2022年
Kobayashi K, Shibata T, Tsuchiya H, Akiyama T. Artificial intelligence-based detection of epileptic discharges from pediatric scalp electroencephalograms: A pilot study. Acta Med Okayama 2022; 76: 617-624. PMID: 36549763
Okazaki Y, Sasaki T, Kawai K, Hosomoto K, Sasada S, Yasuhara T, Akiyama T, Hanaoka Y, Date I. Two cases of monozygotic twins with early-onset isolated (DYT1) dystonia effectively treated with bilateral globus pallidus internus stimulation. NMC Case Rep J 2022; 9: 307-312. Journal website
Hyodo Y, Akiyama T, Fukuyama T, Mimaki M, Watanabe K, Kumagai T, Kobayashi K. Simultaneous assay of urine sepiapterin and creatinine in patients with sepiapterin reductase deficiency. Clin Chim Acta 2022; 534: 167-172. PMID: 35926683
Akiyama T, Kuki I, Kim K, Yamamoto N, Yamada Y, Igarashi K, Ishihara T, Hatano Y, Kobayashi K. Folic acid inhibits 5-methyltetrahydrofolate transport across the blood–cerebrospinal fluid barrier: clinical biochemical data from two cases. JIMD Rep 2022; 63: 529-535. PMID: 36341171
Sugiyama Y, Watanabe T, Tajika M, Matsuhashi T, Shimura M, Fushimi T, Ichimoto K, Matsunaga A, Ebihara T, Tsuruoka T, Akiyama T, Murayama K. A Japanese single-center experience of the efficacy and safety of asfotase alfa in pediatric-onset hypophosphatasia. Orphanet J Rare Dis 2022; 17: 78. PMID: 35197081
Kato M, Kada A, Shiraishi H, Tohyama J, Nakagawa E, Takahashi Y, Akiyama T, Kakita A, Miyake N, Fujita A, Saito MA, Inoue Y. Sirolimus for epileptic seizures associated with focal cortical dysplasia type II. Ann Clin Transl Neurol 2022; 9: 181-192. PMID: 35040598
Inoue Y, Hamano S, Hayashi M, Sakuma H, Hirose S, Ishii A, Honda R, Ikeda A, Imai K, Jin K, Kada A, Kakita A, Kato M, Kawai K, Kawakami T, Kobayashi K, Matsuishi T, Matsuo T, Nabatame S, Okamoto N, Ito S, Okumura A, Saito A, Shiraishi H, Shirozu H, Saito T, Sugano H, Takahashi Y, Yamamoto H, Fukuyama T, Kuki I. Burden of seizures and comorbidities in patients with epilepsy: a survey based on the tertiary hospital-based Epilepsy Syndrome Registry in Japan Epileptic Disord 2022; 24: 82-94. PMID: 35118943
2021年
Takeuchi A, Inoue T, Nakamura M, Kageyama M, Akiyama T, Kobayashi K. Case Report: High-gamma oscillations on an ictal electroencephalogram in a newborn patient with hypoxic-ischemic encephalopathy. Front Pediatr 2021; 9: 679771. PMID: 34660474
Kada A, Tohyama J, Shiraishi H, Takahashi Y, Nakagawa E, Akiyama T, Saito MA, Inoue Y, Kato M. A single-arm open-label clinical trial on the efficacy and safety of sirolimus for epileptic seizures associated with focal cortical dysplasia type II: a study protocol. Kurume Med J 2021; 66: 115-120. PMID: 34135202
Kobayashi K, Shibata T, Tsuchiya H, Akiyama T. Exclusion of the possibility of “false ripples” from ripple band high-frequency oscillations recorded from scalp electroencephalogram in children with epilepsy. Front Hum Neurosci 2021; 15: 696882. PMID: 34211382
Oka M, Kobayashi K, Shibata T, Tsuchiya H, Hanaoka Y, Akiyama M, Morooka T, Akiyama T. A study on the relationship between non-epileptic fast (40-200Hz) oscillations in scalp EEG and development in children. Brain Dev 2021;43:904-911. PMID: 34052035
Hanaoka Y, Akiyama T, Yoshinaga H, Miyamoto R, Kawarai T, Kaji R, Kobayashi K. Monozygotic twins with DYT-TOR1A showing jerking movements and levodopa responsiveness. Brain Dev 2021; 43: 783-788. PMID: 33832800
Shibata T, Kawai H, Sakamoto S, Tsutsui K, Kanbayashi T, Tanaka K, Takaki M. Rituximab was effective for treatment of anti-N-methyl-d-aspartate receptor encephalitis in early adolescence in initially suspected dissociative disorder. Clin Neuropharmacol 2021; 44: 99-100. PMID: 33587488
Miyata H, Fushimi S, Ota Y, Vinters HV, Adachi K, Nanba E, Akiyama T. Isolated cortical tuber in an infant with genetically confirmed tuberous sclerosis complex 1 presenting with symptomatic West syndrome. Neuropathology 2021; 41: 58-64. PMID: 33181865
Furui A, Onishi R, Takeuchi A, Akiyama T, Tsuji T. Non-Gaussianity detection of EEG signals based on a multivariate scale mixture model for diagnosis of epileptic seizures. IEEE Biomed Trans Eng 2021; 68: 515-525. PMID: 32746048
2020年
Takagi M, Kato S, Muto T, Sano Y, Akiyama T, Takagi J, Okumura A, Iwayama H. Odontohypophosphatasia treated with asfotase alfa enzyme replacement therapy in a toddler: a case report. Clin Pediatr Endocrinol 2020; 29: 115-118. PMID: 32694888
Akiyama T, Hyodo Y, Hasegawa K, Oboshi T, Imai K, Ishihara N, Dowa Y, Koike T, Yamamoto T, Shibasaki J, Shimbo H, Fukuyama T, Takano K, Shiraku H, Takeshita S, Okanishi T, Baba S, Kubota M, Hamano S, Kobayashi K. Pyridoxal in the cerebrospinal fluid may be a better indicator of vitamin B6-dependent epilepsy than pyridoxal 5′-phosphate. Pediatr Neurol 2020; 113: 33-41. PMID: 32980745
Nishizawa H, Sato Y, Ishikawa M, Arakawa Y, Iijima M, Akiyama T, Takano K, Watanabe A, Kosho T. Marked improvement in motor function in a 32 year-old woman with childhood hypophosphatasia through asfotase alfa therapy: evaluation based on standardized batteries used in Duchenne muscular dystrophy clinical trials. Mol Genet Metab Rep 2020; 25: 100643. PMID: 32983894
Tsuchiya H, Endoh F, Akiyama T, Matsuhashi M, Kobayashi K. Longitudinal correspondence of epilepsy and scalp EEG fast (40-200 Hz) oscillations in pediatric patients with tuberous sclerosis complex. Brain Dev 2020; 42: 663-674. PMID: 32631641
Shibata T, Otsubo H. Phase-amplitude coupling of delta brush unveiling neuronal modulation development in the neonatal brain. Neurosci Lett 2020; 735: 135211. PMID: 32593774
Kuhara T, Akiyama T, Ohse M, Koike T, Shibasaki J, Imai K, Cooper AJL. Identification of new biomarkers of pyridoxine-dependent epilepsy by GC/MS-based urine metabolomics. Anal Biochem, 2020; 604: 113739. PMID: 32339489
Akiyama T, Toda S, Kimura N, Mogami Y, Hanaoka Y, Tokorodani C, Ito T, Miyahara H, Hyodo Y, Kobayashi K. Vitamin B6 in acute encephalopathy with biphasic seizures and late reduced diffusion. Brain Dev 2020; 42: 402-407. PMID: 32107100
Miyahara H, Akiyama T, Hasegawa K, Akiyama M, Oka M, Kobayashi K, Tsukahara H. Laboratory changes during ACTH therapy associated with renal calcified lesions. Pediatr Int 2020; 62: 587-592. PMID: 31957090
Din F, Lalgudi Ganesan S, Akiyama T, Stewart CP, Ochi A, Otsubo H, Go C, Hahn CD. Seizure detection algorithms in critically ill children: A comparative evaluation. Crit Care Med 2020; 48: 545-552. PMID: 32205601
Koyama H, Yasuda S, Kakoi S, Ohata Y, Shimizu Y, Hasegawa C, Hayakawa A, Akiyama T, Yagi T, Aotani D, Imaeda K, Ozono K, Kataoka H, Tanaka T. Effect of Asfotase Alfa on muscle weakness in a Japanese adult patient of hypophosphatasia with Low ALP levels. Internal Med 2020; 59: 811-815. PMID: 31787692
Dowa Y, Shiihara T, Akiyama T, Hasegawa K, Inoue F, Watanabe M. A case of pyridoxine-dependent epilepsy with novel ALDH7A1 mutations. Oxf Med Case Reports 2020; 3: omaa008. PMID: 32395249
Akiyama T, Saigusa D, Hyodo Y, Umeda K, Saijo R, Koshiba S, Kobayashi K. Metabolic profiling of the cerebrospinal fluid in pediatric epilepsy. Acta Med Okayama 2020; 74: 65-71. PMID: 32099251
Okanari K, Maruyama S, Suzuki H, Shibata T, Pulcine E, Donner EJ, Otsubo H. Autonomic dysregulation in children with epilepsy with postictal generalized EEG suppression following generalized convulsive seizures. Epilepsy Behav 2020; 102: 106688. PMID: 31805503
Kobayashi K, Endoh F, Ohmori I, Akiyama T. Action of antiepileptic drugs on neurons. Brain Dev 2020; 42: 2-5. PMID: 31351738
2019年
Yanagishita T, Yamamoto-Shimojima K, Koike T, Nasu H, Takahashi Y, Akiyama T, Nagata S, Yamamoto T. Compound heterozygous ALDH7A1 mutation causes the hemi-allelic expression in a patient with pyridoxine-dependent epilepsy. Tokyo Women’s Med Univ J 2019; 3: 73-77. Journal website
Yokoi K, Nakajima Y, Shinkai Y, Sano Y, Imamura M, Akiyama T, Yoshikawa T, Ito T, Kurahashi H. Clinical and genetic aspects of mild hypophosphatasia in Japanese patients. Mol Genet Metab Rep 2019; 21: 100515. PMID: 31641588
Ohuchi Y, Akiyama T, Matsuhashi M, Kobayashi K. High-frequency oscillations in a spectrum of pediatric epilepsies characterized by sleep-activated spikes in scalp EEG. Clin Neurophysiol 2019; 130: 1971-1980. PMID: 31476703
Momosaki K, Kido J, Matsumoto S, Taniguchi A, Akiyama T, Sawada T, Ozasa S, Nakamura K. The effect of S-adenosylmethionine treatment on neurobehavioral phenotypes in Lesch-Nyhan disease: a case report. Case Rep Neurol 2019; 11: 256-264. PMID: 31607891
Yamamoto T, Imaizumi T, Yamamoto-Shimojima K, Lu Y, Yanagishita T, Shimada S, Chong PF, Kira R, Ueda R, Ishiyama A, Takeshita E, Momosaki K, Ozasa S, Akiyama T, Kobayashi K, Oomatsu H, Kitahara H, Yamaguchi T, Imai K, Kurahashi H, Okumura A, Oguni H, Seto T, Okamoto N. Genomic backgrounds of Japanese patients with undiagnosed neurodevelopmental disorders. Brain Dev 2019; 41: 776-782. PMID: 31171384
Ishiguro T, Sugiyama Y, Ueda K, Muramatsu Y, Tsuda H, Kotani T, Michigami T, Tachikawa K, Akiyama T, Hayakawa M. Findings of amplitude-integrated electroencephalogram recordings and serum vitamin B6 metabolites in perinatal lethal hypophosphatasia during enzyme replacement therapy. Brain Dev 2019; 41: 721-725. PMID: 31000369
Takeuchi A, Yorifuji T, Hattori M, Tamai K, Nakamura K, Nakamura M, Kageyama M, Kubo T, Ogino T, Kobayashi K, Doi H. Catch-up growth and behavioral development among preterm, small-for-gestational-age children: a nationwide Japanese population-based study. Brain Dev 2019; 41: 397-405. PMID: 30611596
Tsuchiya H, Akiyama T, Kuhara T, Nakajima Y, Ohse M, Kurahashi H, Kato T, Maeda Y, Yoshinaga H, Kobayashi K. A case of dihydropyrimidinase deficiency incidentally detected by urine metabolome analysis. Brain Dev 2019; 41: 280-284. PMID: 30384990
2018年
Shibata K, Kobayashi K. Epileptic high-frequency oscillations in scalp electroehcephalography. Acta Med Okayama 2018; 72: 325-329. PMID: 30140078
Akiyama T, Kubota T, Ozono K, Michigami T, Kobayashi D, Takeyari S, Sugihara Y, Noda M, Harada D, Namba N, Suzuki A, Utoyama M, Kitanaka S, Uematsu M, Mitani Y, Matsunami K, Takishima S, Ogawa E, Kobayashi K. Pyridoxal 5′-phosphate and related metabolites in hypophosphatasia: effects of enzyme replacement therapy. Mol Genet Metab 2018; 125: 174-180. PMID: 30049651
Miyahara H, Akiyama T, Waki K, Arakaki Y. Differential diagnosis of nonepileptic twilight state with convulsive manifestations after febrile seizures. Brain Dev 2018; 40: 781-785. PMID: 29866486
Oyachi M, Harada D, Sakamoto N, Ueyama K, Kondo K, Kishimoto K, Izui M, Nagamatsu Y, Kashiwagi H, Yamamuro M, Tamura M, Kikuchi S, Akiyama T, Michigami T, Seino Y, Namba N. A case of perinatal hypophosphatasia with a novel mutation in the ALPL gene: clinical course and review of the literature. Clin Pediatr Endocrinol 2018; 27: 179-186. PMID: 30083035
Takeuchi A, Koeda T, Ogino T, Oka M, Yorifuji T, Takayanagi T, Sato K, Sugino N, Bonno M, Nakamura M, Kageyama M. Intelligence test at preschool-age predicts reading difficulty among school-aged very low birth weight infants in Japan. Brain Dev 2018; 40: 735-742. PMID: 29793755
Kobayashi K, Ohuchi Y, Shibata T, Hanaoka Y, Akiyama M, Oka M, Endoh F, Akiyama T. Detection of fast (40-150 Hz) oscillations from the ictal scalp EEG data of myoclonic seizures in pediatric patients. Brain Dev 2018; 40: 397-405. PMID: 29395662
Iimura Y, Jones K, Takada L, Shimizu I, Koyama M, Hattori K, Okazawa Y, Nonoda Y, Asano E, Akiyama T, Go C, Ochi A, Snead OC 3rd, Donner EJ, Rutka JT, Drake JM, Otsubo H. Strong coupling between slow oscillations and wide fast ripples in children with epileptic spasms: Investigation of modulation index and occurrence rate. Epilepsia 2018; 50: 544-554. PMID: 29315516
Takeuchi A, Yorifuji T, Nakamura K, Tamai K, Mori S, Nakamura M, Kageyama M, Kubo T, Ogino T, Kobayashi K, Doi H. Catch-up growth and neurobehavioral development among full term, small-for-gestational-age children: a nationwide Japanese population-based study. J Pediatr 2018; 192: 41-46. PMID: 29092752
2017年
Frauscher B, Bartolomei F, Kobayashi K, Cimbalnik J, van’t Klooster MA, Rampp S, Otsubo H, Holler Y, Wu JY, Asano E, Engel J Jr, Kahane P, Jacobs J, Gotman J. High-frequency oscillations: The state of clinical research. Epilepsia 2017; 58: 1316-1329. PMID: 28666056
Akiyama T, Hayashi Y, Hanaoka Y, Shibata T, Akiyama M, Tsuchiya H, Yamaguchi T, Kobayashi K. Pyridoxal 5′-phosphate, pyridoxal, and 4-pyridoxic acid in the paired serum and cerebrospinal fluid of children. Clin Chim Acta 2017; 472: 118-122. PMID: 28778380
Shibata T, Kobayashi K, Yoshinaga H, Ono H, Shinpo M, Kagitani-Shimono K. Another case of glucose transporter 1 deficiency syndrome with periventricular calcification, cataracts, hemolysis, and pseudohyperkalemia. Neuropediatrics 2017; 48: 390-393. PMID: 28582795
Kobayashi K, Akiyama T, Agari T, Sasaki T, Shibata T, Hanaoka Y, Akiyama M, Endoh F, Oka M, Date I. Significance of high-frequency electrical brain activity. Acta Med Okayama 2017; 71: 191-200. PMID: 28655938
Iimura Y, Jones K, Hattori K, Okazawa Y, Noda A, Hoashi K, Nonoda Y, Asano E, Akiyama T, Go C, Ochi A, Snead OC III, Donner EJ, Rutka JT, Drake JM, Otsubo H. The epileptogenic high frequency oscillations skipping the motor area in children with multilobar drug-resistant epilepsy. Clin Neurophysiol 2017; 128: 1197-1205. PMID: 28521267
Kobayashi K, Endoh F, Agari T, Akiyama T, Akiyama M, Hayashi Y, Shibata T, Hanaoka Y, Oka M, Yoshinaga H, Date I. Complex observation of scalp fast (40-150 Hz) oscillations in West syndrome and related disorders with structural brain pathology. Epilepsia Open 2017; 2: 260-266. PMID: 29588955
Hanaoka Y, Yoshinaga H, Kobayashi K. A ten-year follow-up cohort study of childhood epilepsy: changes in epilepsy diagnosis with age. Brain Dev 2017; 39: 312-320. PMID: 27847129
Akiyama T, Akiyama M, Hayashi Y, Shibata T, Hanaoka Y, Toda S, Imai K, Hamano S, Okanishi T, Yoshinaga H, Kobayashi K. Measurement of pyridoxal 5′-phosphate, pyridoxal, and 4-pyridoxic acid in the cerebrospinal fluid of children. Clin Chim Acta 2017; 466: 1-5. PMID: 28040557
Kobayashi Y, Tohyama J, Akiyama T, Magara S, Kawashima H, Akasaka N, Nakashima M, Saitsu H, Matsumoto N. Severe leukoencephalopathy with cortical involvement and peripheral neuropathy due to FOLR1 deficiency. Brain Dev 2017; 39: 266-270. PMID: 27743887
Ogino T, Hanafusa K, Morooka T, Takeuchi A, Oka M, Ohtsuka Y. Predicting the reading skill of Japanese children. Brain Dev 2017; 39: 112-121. PMID: 27637722
Takeuchi A, Yorifuji T, Takahashi K, Nakamura M, Kageyama M, Kubo T, Ogino T, Kobayashi K, Doi H. Behavioral outcomes of school-aged full-term small-for-gestational-age infants: a nationwide Japanese population-based study. Brain Dev 2017; 39: 101-106. PMID: 27622852
Akiyama T, Hayashi Y, Hanaoka Y, Shibata T, Akiyama M, Nakamura K, Tsuyusaki Y, Kubota M, Yoshinaga H, Kobayashi K. Simultaneous measurement of monoamine metabolites and 5-methyltetrahydrofolate in the cerebrospinal fluid of children. Clin Chim Acta 2017; 465: 5-10. PMID: 27940130
Kobayashi Y, Hanaoka Y, Akiyama T, Ohmori I, Ouchida M, Yamamoto T, Oka M, Yoshinaga H, Kobayashi K. A case of Dravet syndrome with cortical myoclonus indicated by jerk-locked back-averaging of electroencephalogram data. Brain Dev 2017; 39:75-79. PMID: 27523882
Akiyama T, Shibata T, Yoshinaga H, Kuhara T, Nakajima Y, Kato T, Maeda Y, Ohse M, Oka M, Kageyama M, Kobayashi K. A Japanese case of β-ureidopropionase deficiency with dysmorphic features. Brain Dev 2017; 39: 58-61. PMID: 27553092
